New Orleans Saints vs. Seattle Seahawks (1:35 pm PT/3:35 pm CT, Fox) - Last week, Drew Brees finally won a road game, beating the Eagles 26-23. This week, he and his high-powered offense have a much bigger task: playing in the nosiest, most hostile environment in football that is CenturyLink Field, and playing perhaps the toughest defense in the NFC. Seattle's coming off a bye-week, and now face the task of figuring out how to better protect their QB, Russell Wilson from the Saint's very tough front seven.
My pick: Seahawks - To me, this team has just too good a running game (Marshawn Lynch is a beast) and too deep on defense to let Brees pick them apart. He has the weapons on offense, but I'm not sure how he - or players like Jimmy Graham and Marques Coleston will fare against the league's best passing defense (just 172 passing yards given up per game).
Indianapolis Colts vs. New England Patriots (5:15 pm PT/7:15 pm CT, CBS) - Like most of us, I was surprised how Andrew Luck led his Colts from a 20+ deficit and beat the Chiefs 45-44 last Saturday. This week, he'll be squaring off against Tom Brady and a Patriots team that's quite simply not the same, frightening team we've seen in year's past: Wes Welker left to play with Denver, Rob Gronkowski is out with a torn ACL, and Aaron Hernandez is standing trial for murder. The good news is that Colts wide receiver T.Y. Hilton will be out for tonight's game; not because he's injured, but because Bill Belichick will make sure he's as much of a non-factor as possible.
My pick: Colts - Like I said, New England doesn't scare me like they have everyone. Brady doesn't have the same offensive firepower, and although their defense is decent, I believe in the abilities of Andrew Luck and that Trent Richardson will come alive - or, at least, give Indy some resemblance of a running game.